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Engineering XXX XXX Nickase for Robust Base Editing with Broad Targeting Range

Robust miniature Cas-based transcriptional modulation by engineering Un1Cas12f1 and tethering Sso7d

Engineering Miniature CRISPR-Cas Un1Cas12f1 for Efficient Base Editing

Tracking paired-wise genomic loci by the  ParB–ParS and Noc-NBS systems in living cells

Latest news

Jun. 08,2023, Congratulations to Yuxi Tan (谭宇希) and Lingyun Li (李凌云) to become Ph.D. students.

April. 26,2023, "The local density of H3K9me3 dictates the stability of HP1a condensates-mediated genomic interactions" was published in Journal of Genetics and Genomics. Congratulation to Feng Ying (冯颖) in our lab

Jan. 01,2023, Congratulations to Yingdi Zhao(赵英迪) join the lab.

Dec. 01,2022, Congratulations to Wenlong Sun(孙文龙) to graduate.

Jun. 20,2022, Congratulations to Siyuan Liu(刘思远) to become Ph.D. students.

April. 6,2022, We posted our manuscript "Enhancing Prime Editing Efficiency and Flexibility with Tethered and Split pegRNAs" on Protein & Cell.

Jan. 1, 2022, Welcome Yuxi Tan (谭宇希) and Lingyun Li (李凌云) join the lab.

May. 14,2021, Congratulations to Xiaohui He(何晓慧) and Linxiao Han(韩林晓) to become Ph.D. students.

March. 15, 2021, Welcome Dingzhe Pu (濮定哲)Qiqin Mo (莫淇钦) joined in the lab.

Jan. 1, 2021, Welcome Siyuan Liu (刘思远) joined in the lab.

Dec. 8, 2020, Our EpiGo system was published in Genome Biology. Congratulation to Feng Ying (冯颖) in our lab and Yao Wang (王瑶) in Wei Xie's lab at Tsinghua University.